Functional Analysis of In-frame Indel ARID1A Mutations Reveals New Regulatory Mechanisms of Its Tumor Suppressor Functions

AT-rich interactive domain 1A (ARID1A) has emerged as a new tumor suppressor Sundries in which frequent somatic mutations have been identified in several types of human cancers.Although most ARID1A somatic mutations are frame-shift or nonsense mutations that contribute to mRNA decay and loss of protein expression, 5% of ARID1A mutations are in-fram

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Inverse Kinematics Solution of Articulated Robots Using a Heuristic Approach for Optimizing Joint Displacement

In this work, a new constrained numerical optimization approach is proposed for solving offline the Inverse Kinematics Problem (IKP) of articulated robots, which consists on optimizing the joint displacement while the end effector is positioned and oriented in a desired pose.The novelty of this approach is in the formulation of the optimization pro

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